Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation
AK Rahm, D Gramlich, T Wieder… - Pharmacogenomics …, 2021 - Taylor & Francis
Aim Effective antiarrhythmic treatment of atrial fibrillation (AF) constitutes a major challenge,
in particular, when concomitant heart failure (HF) is present. HF-associated atrial …
in particular, when concomitant heart failure (HF) is present. HF-associated atrial …
Differential regulation of KCa2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure
AK Rahm, T Wieder, D Gramlich, ME Müller… - Physiological …, 2021 - Wiley Online Library
Atrial fibrillation (AF) with concomitant heart failure (HF) poses a significant therapeutic
challenge. Mechanism‐based approaches may optimize AF therapy. Small‐conductance …
challenge. Mechanism‐based approaches may optimize AF therapy. Small‐conductance …
HDAC2-dependent remodeling of KCa2. 2 (KCNN2) and KCa2. 3 (KCNN3) K+ channels in atrial fibrillation with concomitant heart failure
AK Rahm, T Wieder, D Gramlich, ME Müller… - Life Sciences, 2021 - Elsevier
Aims Atrial fibrillation (AF) with concomitant heart failure (HF) is associated with prolonged
atrial refractoriness. Small-conductance, calcium-activated K+(K Ca, KCNN) channels …
atrial refractoriness. Small-conductance, calcium-activated K+(K Ca, KCNN) channels …
Atrium-specific Kir3. x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans
BO Bingen, Z Neshati, SFA Askar, IV Kazbanov… - Circulation, 2013 - Am Heart Assoc
Background—Atrial fibrillation is the most common cardiac arrhythmia. Ventricular
proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium …
proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium …
Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific …
C Schmidt, F Wiedmann, XB Zhou… - European Heart …, 2017 - academic.oup.com
Aims Atrial fibrillation (AF) prevalence increases with advanced stages of left ventricular (LV)
dysfunction. Remote proarrhythmic effects of ventricular dysfunction on atrial …
dysfunction. Remote proarrhythmic effects of ventricular dysfunction on atrial …
[HTML][HTML] Excitation-Contraction Coupling, Electrophysiology, and Arrhythmias: Dual effects of the small-conductance Ca2+-activated K+ current on human atrial …
NT Herrera, X Zhang, H Ni, MM Maleckar… - American Journal of …, 2023 - ncbi.nlm.nih.gov
By sensing changes in intracellular Ca 2+, small-conductance Ca 2+-activated K+(SK)
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
[HTML][HTML] Unraveling the role of K2P channels in atrial fibrillation
G Mondéjar-Parreño - Frontiers in Bioscience-Scholar, 2022 - imrpress.com
Atrial fibrillation (AF) is a condition in which the electrical signals in the upper heart
chambers (atria) are rapid and disorganized, producing an irregular and chaotical heartbeat …
chambers (atria) are rapid and disorganized, producing an irregular and chaotical heartbeat …
[HTML][HTML] In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis
A recent experimental study investigating patients with lone atrial fibrillation identified six
novel mutations in the KCNA5 gene. The mutants exhibited both gain-and loss-of-function of …
novel mutations in the KCNA5 gene. The mutants exhibited both gain-and loss-of-function of …
Populations of in silico myocytes and tissues reveal synergy of multiatrial‐predominant K+‐current block in atrial fibrillation
H Ni, A Fogli Iseppe, WR Giles… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Pharmacotherapy of atrial fibrillation (AF), the most common
cardiac arrhythmia, remains unsatisfactory due to low efficacy and safety concerns. New …
cardiac arrhythmia, remains unsatisfactory due to low efficacy and safety concerns. New …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …