Purpose The aim of this study was to determine the impact of ABCB1 (MDR1) rs1045642
polymorphisms on the efficacy and safety of amlodipine in Caucasian patients. Patients and …

An open, non-comparative, prospective clinical study was conducted to evaluate the
antihypertensive efficacy and tolerability of amlodipine, a calcium antagonist, in patients with …

The effects of genetic polymorphisms of ABCB1 C3435T, POR* 28, CYP3A4* 1G and
CYP3A5* 3 variants and gender relating to metabolism on the exposure and response of …

The aim of the present study was to explore the effects of common genetic polymorphisms of
cytochrome P450 (CYP) 3A4, CYP3A5, cytochrome P450 oxidoreductase (POR) and …

Aim We aimed to investigate the effect of the ABCB1 gene on the pharmacokinetics of
amlodipine. Methods Based on polymorphisms of the ABCB1 gene at positions 2677 and …

Objective To investigate the associations between β1-adrenergic receptor (ADRB1) and
cytochrome P450 2D6 (CYP2D6) gene polymorphisms and β-blocker treatment outcomes in …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The pharmacokinetics of verapamil
have been assessed in a number of studies.• As a substrate of P‐glycoprotein (P‐gp) …

Background Few studies have examined the effect of the angiotensin II type I receptor
(AT1R) A1166C polymorphism on the antihypertensive effect of the angiotensin-converting …

Background Genetic factors have a vital influence on the pathogenesis of hypertension. In
this retrospective study, we aimed to evaluate the association of ADRB1 and CYP2D6 …

Objective: Previous studies have determined that CYP3A and multidrug resistance protein 1
(MDR1) polymorphisms can affect the pharmacokinetics and pharmacodynamics of …