Cellular therapy with CD4+FOXP3+ T regulatory (Treg) cells is a promising strategy to
induce tolerance after solidorgan transplantation or prevent graft-versus-host disease after …

Knowledge of how Tregs work in transplantation comes from studies that do not recapitulate
how these cells will be used in humans. There is a need to develop better preclinical models …

Graft survival has been lately improved by the introduction of efficient immunosuppressive
drugs. However, late graft loss caused by chronic rejection and the side effects of long‐term …

Abstract FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and
homeostasis of the immune system. The molecular mechanisms underlying the stability …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …

Abstract The CD4+ FOXP3+ regulatory T (Treg) cells are essential for maintaining immune
homeostasis in healthy individuals. Results from clinical trials of Treg cell-based therapies in …

Advances in immunosuppressive therapies have made tissue and organ transplantation a
common procedure in clinical medicine. However, true donor and recipient tolerance is not …

Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …

Abstract CD4+ CD25highCD127low/− FOXP3+ T regulatory cells are responsible for
maintaining immune tolerance and controlling excessive immune responses. Treg cell use …