Immunomodulating regulatory T-cell (Treg) therapy is a promising strategy in autoimmunity
and transplantation. However, to achieve full clinical efficacy, better understanding of in vivo …

The adoptive transfer of donor-type CD4+ CD25+ FOXP3+ regulatory T cells (Treg) protects
from graft-versus-host disease in murine bone marrow transplantation models. Results from …

Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be
challenging in post transplantation management. The introduction of calcineurin inhibitors …

T regulatory cells (Tregs) are key players in immune regulation of both physiological and
pathophysiological conditions. There are different Treg subsets but they can be divided into …

Abstract Forkhead box P3 (FOXP3)-expressing regulatory T (TReg) cells have a pivotal role
in the regulation of immune responses and in the maintenance of immunological self …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Organ transplantation is the preferred treatment option for end-stage organ failure. Although
immunosuppressants are effective for preventing the occurrence of acute rejection, they also …

Abstract Foxp3+ regulatory T (Treg) cells are considered a sub-lineage of CD4+ T cells that
are protective against autoimmunity due to their essential roles in maintaining immune …

Abstract CD4+ CD25 high FoxP3+ T regulatory cells (Tregs) are immunodominant
suppressors in the immune system. Tregs use various mechanisms to control immune …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …