Thymus-Derived, Peripherally Derived, and in vitro-Induced T Regulatory Cells
E Elkord - Frontiers in immunology, 2014 - frontiersin.org
T regulatory cells (Tregs) are key players in immune regulation of both physiological and
pathophysiological conditions. There are different Treg subsets but they can be divided into …
pathophysiological conditions. There are different Treg subsets but they can be divided into …
Perspectives on regulatory T cell therapies
M Probst-Kepper, A Kröger, HSP Garritsen… - Transfusion Medicine …, 2009 - karger.com
Adoptive transfer in animal models clearly indicate an essential role of CD4+ CD25+
FOXP3+ regulatory T (Treg) cells in prevention and treatment of autoimmune and graft …
FOXP3+ regulatory T (Treg) cells in prevention and treatment of autoimmune and graft …
Regulatory T cell homeostasis: requisite signals and implications for clinical development of biologics
N Skartsis, YD Muller, LMR Ferreira - Clinical Immunology, 2023 - Elsevier
Novel biologics are currently being tested in clinical trials for the treatment of autoimmune
diseases and the prevention of transplant allograft rejection. Their premise is to deliver …
diseases and the prevention of transplant allograft rejection. Their premise is to deliver …
Immunotherapy with regulatory T cells in transplantation
JH Peters, HJPM Koenen, LB Hilbrands… - Immunotherapy, 2009 - Taylor & Francis
Regulatory T cell (Treg)-based immunotherapy is of great interest to induce tolerance in
clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell …
clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell …
Direct expansion of human allospecific FoxP3+ CD4+ regulatory T cells with allogeneic B cells for therapeutic application
LC Chen, JC Delgado, PE Jensen… - The Journal of …, 2009 - journals.aai.org
Compelling evidence from animal studies has demonstrated that allospecific FoxP3+ CD4+
regulatory T (Treg) cells expanded ex vivo can be used as effective therapeutic tools in the …
regulatory T (Treg) cells expanded ex vivo can be used as effective therapeutic tools in the …
Heterogeneity and stability in Foxp3+ regulatory T cells
B Min - Journal of Interferon & Cytokine Research, 2017 - liebertpub.com
Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and
immunity against self-and foreign antigens. The failure of Tregs to properly function is the …
immunity against self-and foreign antigens. The failure of Tregs to properly function is the …
Regulatory T cells from allo‐to xenotransplantation: Opportunities and challenges
MB Ezzelarab - Xenotransplantation, 2018 - Wiley Online Library
Regulatory T cells (Treg) are currently being evaluated in clinical allotransplantation for
tolerance induction, with proven safety in humans with autoimmune diseases and graft …
tolerance induction, with proven safety in humans with autoimmune diseases and graft …
Non-human primate regulatory T cells: current biology and implications for transplantation
EM Dons, G Raimondi, DKC Cooper… - Transplantation, 2010 - journals.lww.com
Regulatory T cells (Treg) offer potential for improving long-term outcomes in cell and organ
transplantation. The non-human primate model is a valuable resource for addressing issues …
transplantation. The non-human primate model is a valuable resource for addressing issues …
Stabilizing human regulatory T cells for tolerance inducing immunotherapy
X He, HJPM Koenen, JHR Slaats, I Joosten - Immunotherapy, 2017 - Taylor & Francis
Many autoimmune diseases develop as a consequence of an altered balance between
autoreactive immune cells and suppressive FOXP3+ Treg. Restoring this balance through …
autoreactive immune cells and suppressive FOXP3+ Treg. Restoring this balance through …