T regulatory cells (Tregs) are key players in immune regulation of both physiological and
pathophysiological conditions. There are different Treg subsets but they can be divided into …

Adoptive transfer in animal models clearly indicate an essential role of CD4+ CD25+
FOXP3+ regulatory T (Treg) cells in prevention and treatment of autoimmune and graft …

Novel biologics are currently being tested in clinical trials for the treatment of autoimmune
diseases and the prevention of transplant allograft rejection. Their premise is to deliver …

Regulatory T cell (Treg)-based immunotherapy is of great interest to induce tolerance in
clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell …

Summary Foxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with
immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic …

Compelling evidence from animal studies has demonstrated that allospecific FoxP3+ CD4+
regulatory T (Treg) cells expanded ex vivo can be used as effective therapeutic tools in the …

Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and
immunity against self-and foreign antigens. The failure of Tregs to properly function is the …

Regulatory T cells (Treg) are currently being evaluated in clinical allotransplantation for
tolerance induction, with proven safety in humans with autoimmune diseases and graft …

Regulatory T cells (Treg) offer potential for improving long-term outcomes in cell and organ
transplantation. The non-human primate model is a valuable resource for addressing issues …

Many autoimmune diseases develop as a consequence of an altered balance between
autoreactive immune cells and suppressive FOXP3+ Treg. Restoring this balance through …