Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and
immunity against self-and foreign antigens. The failure of Tregs to properly function is the …

Regulatory T cells (Treg) are currently being evaluated in clinical allotransplantation for
tolerance induction, with proven safety in humans with autoimmune diseases and graft …

Regulatory CD4+ Foxp3+ T cells (Tregs) are critical in controlling immunity and tolerance.
Thus, preserving Treg numbers and function in transplanted patients is essential for the …

Transplantation is a successful treatment for end-stage organ failure. Despite improvements
in short-term outcome, long-term survival remains suboptimal because of the morbidity and …

Cell-based therapy with CD4+ FOXP3+ regulatory T cells (Tregs) is a promising strategy to
limit organ rejection and graft-vs-host disease. Ongoing clinical applications have yet to …

The initial idea of a distinct group of T-cells responsible for suppressing immune responses
was first postulated half a century ago. However, it is only in the last three decades that we …

Foxp3+ regulatory T (Treg) cells are a CD4 T cell subset with unique immune regulatory
function that are indispensable in immunity and tolerance. Their indisputable importance …

The involvement of CD4+ CD25+ regulatory T cells (Treg) in general immune homeostasis
and protection from autoimmune syndromes is now well established. Similarly, there has …

Recognition of the ability of CD4+ FoxP3+ T cells (Treg) to influence the generation of
peripheral immune responses has engendered enthusiasm for the development of …

From mouse studies to recently published clinical trials, evidence has accumulated on the
potential use of regulatory T cells (Treg) in preventing and treating graft-versus-host disease …