The Tuberculosis Drug Accelerator at year 10: what have we learned?

BB Aldridge, D Barros-Aguirre, CE Barry III, RH Bates… - Nature medicine, 2021 - nature.com
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in
tuberculosis drug discovery by breaking down barriers among competing labs and …

[HTML][HTML] Changing funding patterns in tuberculosis

SHE Kaufmann, SK Parida - Nature Medicine, 2007 - nature.com
Exactly 125 years after the discovery of the etiological agent of tuberculosis (TB), the
disease remains as threatening as ever. The insufficient control measures in place today …

A portfolio model of drug development for tuberculosis

SW Glickman, EB Rasiel, CD Hamilton, A Kubataev… - Science, 2006 - science.org
Published by AAAS (see figure, this page, top). However, the likelihood of the portfolio's
generating at least one successful compound by 2010 is less than 5%. As expected, when …

The challenge of new drug discovery for tuberculosis

A Koul, E Arnoult, N Lounis, J Guillemont, K Andries - Nature, 2011 - nature.com
Tuberculosis (TB) is more prevalent in the world today than at any other time in human
history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse …

Tuberculosis, a neglected opportunity?

C Harper - Nature medicine, 2007 - nature.com
Historically, tuberculosis (TB) has fallen firmly in the group of 'neglected diseases'—
diseases in which pharmaceutical companies have been reluctant to invest due to a …

The 1/4/6x24 campaign to cure tuberculosis quickly

L McKenna, M Frick, K Angami, V Dubula, J Furin… - Nature Medicine, 2023 - nature.com
The “right of everyone to enjoy the benefits of scientific progress and its applications,” also
known as the right to science, is enshrined in the Universal Declaration of Human Rights …

[HTML][HTML] Is the development of a new tuberculosis vaccine possible?

SHE Kaufmann - Nature medicine, 2000 - nature.com
“Since the time people have realised tuberculosis is preventable and since they have
learned how to avoid infection, mortality rates caused by tuberculosis have declined in …

[HTML][HTML] Challenges in tuberculosis drug research and development

AM Ginsberg, M Spigelman - Nature medicine, 2007 - nature.com
The present decade has seen a reawakening of tuberculosis (TB) drug research and
development (R&D), spurred on by an urgent need to stem the tide of the disease globally …

Tuberculosis: what we don't know can, and does, hurt us

DG Russell, CE Barry 3rd, JAL Flynn - Science, 2010 - science.org
Mycobacterium tuberculosis has a penetrance of its host population that would be the envy
of most human pathogens. About one-third of the human population would have a positive …

[HTML][HTML] New approaches to filling the gap in tuberculosis drug discovery

M Casenghi, ST Cole, CF Nathan - PLoS medicine, 2007 - journals.plos.org
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