The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

We are increasingly aware that cellular metabolism plays a vital role in diseases such as
cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

During the course of tumorigenesis, cells acquire a number of alterations that contribute to
the acquisition of the malignant phenotype, allowing them to survive and flourish in …

The metabolic changes that occur in a cancer cell have been studied for a few decades, but
our appreciation of the complexity and importance of those changes is now being realized …

Virtually all cancers show metabolic changes that result in upregulation of glycolysis and
glucose consumption. Although discovered in the 1920s, how this glycolytic switch happens …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Metabolism plays critical roles in maintaining the homeostasis of cells. Metabolic
abnormalities are often considered as one of the main driving forces for cancer progression …