[HTML][HTML] Pediatric use of tetracyclines: focus on neurodevelopmental effects

I Inta, GF Hoffmann, M Bettendorf - Pediatric Research, 2017 - nature.com
Tetracyclines represent important antibiotics that are in clinical use since many decades,
particularly effective in treating infections with intracellular agents, such as mycoplasma and …

Paradoxical effects of minocycline in the developing mouse somatosensory cortex

I Arnoux, M Hoshiko, A Sanz Diez, E Audinat - Glia, 2014 - Wiley Online Library
Minocycline, a tetracycline derivative, is known to exert neuroprotective effects unrelated to
its antimicrobial action. In particular, minocycline prevents microglial activation in …

Neuroprotection by tetracyclines

M Domercq, C Matute - Trends in pharmacological sciences, 2004 - cell.com
The neuroprotective properties of tetracyclines have been clearly established in rodent
models of acute and chronic neurodegeneration during the past few years. Recent findings …

Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia

R Filipovic, N Zecevic - Experimental neurology, 2008 - Elsevier
Bacterial infections during pregnancy often result in premature birth and neonatal white
matter damage. During these infections, microglia, the resident immune cells of the CNS …

Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease

D Orsucci, V Calsolaro, M Mancuso… - CNS & Neurological …, 2009 - ingentaconnect.com
Tetracyclines are a class of antibiotics which could play a therapeutic role in several
neurological disorders. Minocycline, extensively studied in animal models, decreased the …

[引用][C] Tetracycline update

SL Zeichner - Pediatrics in Review, 1998 - publications.aap.org
Although the tetracyclines stain the enamel of growing teeth and are taken up in the bones
of younger patients, they still have great use in some clinical situations. They are the drugs …

Minocycline causes widespread cell death and increases microglial labeling in the neonatal mouse brain

JA Strahan, WH Walker… - Developmental …, 2017 - Wiley Online Library
Minocycline, an antibiotic of the tetracycline family, inhibits microglia in many paradigms and
is among the most commonly used tools for examining the role of microglia in physiological …

[HTML][HTML] A pilot open-label trial of minocycline in patients with autism and regressive features

CA Pardo, A Buckley, A Thurm, LC Lee… - Journal of …, 2013 - Springer
Background Minocycline is a tetracycline derivative that readily crosses the blood brain
barrier and appears to have beneficial effects on neuroinflammation, microglial activation …

Minocycline and Pseudotumor cerebri: The Well-Known but Well-Kept Secret

DE Weese-Mayer, RJ Yang, JR Mayer… - Pediatrics, 2001 - publications.aap.org
Minocycline, a synthetic derivative of tetracycline, is the most widely prescribed oral systemic
antibiotic for acne vulgaris because it does not appear to induce resistance in …

Short-term, preweaning treatment with tetracycline affects physical development and behavior in rats.

ML Seo, A Yamatodani, A Mizutani, S Kiyono - Neurotoxicology, 1993 - europepmc.org
Tetracycline (TC) was administered indirectly to rat pups through maternal milk, giving
mothers diluted TC solutions as a single source of drinking water, during 13-16 days of …