Ultimate translation: developing therapeutics targeting on N-methyl-d-aspartate receptor
GE Tsai - Advances in Pharmacology, 2016 - Elsevier
N-Methyl-d-aspartate receptors (NMDARs) are broadly distributed in the central nervous
system (CNS), where they mediate excitatory signaling. NMDAR-mediated …
system (CNS), where they mediate excitatory signaling. NMDAR-mediated …
Enhancing NMDA receptor function: recent progress on allosteric modulators
L Yao, Q Zhou - Neural Plasticity, 2017 - Wiley Online Library
The N‐methyl‐D‐aspartate receptors (NMDARs) are subtype glutamate receptors that play
important roles in excitatory neurotransmission and synaptic plasticity. Their hypo‐or …
important roles in excitatory neurotransmission and synaptic plasticity. Their hypo‐or …
[HTML][HTML] N-methyl-D-aspartate receptor hypofunction as a potential contributor to the progression and manifestation of many neurological disorders
B Dong, Y Yue, H Dong, Y Wang - Frontiers in Molecular …, 2023 - frontiersin.org
N-methyl-D-aspartate receptors (NMDA) are glutamate-gated ion channels critical for
synaptic transmission and plasticity. A slight variation of NMDAR expression and function …
synaptic transmission and plasticity. A slight variation of NMDAR expression and function …
How could N-methyl-D-aspartate receptor antagonists lead to excitation instead of inhibition?
T Su, Y Lu, Y Geng, W Lu, Y Chen - Brain Science Advances, 2018 - journals.sagepub.com
N-methyl-D-aspartate receptors (NMDARs) are a family of ionotropic glutamate receptors
mainly known to mediate excitatory synaptic transmission and plasticity. Interestingly, low …
mainly known to mediate excitatory synaptic transmission and plasticity. Interestingly, low …
[HTML][HTML] Modulation of NMDA receptors: from bench side to clinical applications in psychiatry
N Petronijević, HY Lane, NV Radonjić - Frontiers in Psychiatry, 2022 - frontiersin.org
N-methyl-D-aspartate receptors (NMDARs) have a complex role in the developing and
mature brain. Disruptions in NMDAR signaling have been observed in different psychiatric …
mature brain. Disruptions in NMDAR signaling have been observed in different psychiatric …
Mechanisms of NMDA receptor regulation
L Mony, P Paoletti - Current Opinion in Neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …
expressed in the central nervous system that play key role in brain development and …
Molecular mechanisms underlying the N-methyl-d-aspartate receptor antagonists: highlighting their potential for transdiagnostic therapeutics
The so-called “psychedelic renaissance” has stimulated expanded interest in several
classes of drugs that appear to possess transdiagnostic effects in the treatment of mental …
classes of drugs that appear to possess transdiagnostic effects in the treatment of mental …
Whole-cell patch-clamp analysis of recombinant NMDA receptor pharmacology using brief glutamate applications
NG Glasgow, JW Johnson - Patch-Clamp Methods and Protocols, 2014 - Springer
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that are
essential for synaptic plasticity, learning and memory. Dysfunction of NMDARs has been …
essential for synaptic plasticity, learning and memory. Dysfunction of NMDARs has been …
Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of Action
ES Burnell, M Irvine, G Fang, K Sapkota… - Journal of medicinal …, 2018 - ACS Publications
Excitatory activity in the CNS is predominately mediated by l-glutamate through several
families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate …
families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate …
[HTML][HTML] GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics
V Ugale, R Deshmukh, D Lokwani… - Molecular Diversity, 2023 - Springer
N-methyl-D-aspartate receptors (NMDARs) play essential roles in vital aspects of brain
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …