First‐dose‐in‐children relies on the prediction of clearance from adults for which little
information is available on the accuracy of the scaling‐approaches applied. For CYP3A …

Drug metabolism in the intestinal wall affects bioavailability of orally administered drugs and
is influenced by age. Hence, it is important to fully understand the drug metabolizing …

Aims Develop a population pharmacokinetic model describing propofol pharmacokinetics in
(pre) term neonates and infants, that can be used for precision dosing (eg during target …

In addition to size-dependent allometric metabolic activity, most isoenzymes display age-
dependent isoenzyme-specific ontogeny. We therefore need probe drugs to describe …

After the transition from in utero to newborn life, the neonate becomes solely reliant upon its
own drug clearance processes to metabolise xenobiotics. Whilst most studies of neonatal …

The hepatic extraction ratio (EH) is commonly considered an “inherent attribute” of drug. It
determines the main physiological and biological elements of the system (patient attributes) …

Interventions The pharmacokinetics of midazolam and metabolites were determined during
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …

The use of midazolam in early stages of pregnancy has resulted in a high incidence of birth
defects; however, the underlying reason is unknown. We investigated expression changes …

A paucity of data exists on the disposition and effect of drugs in young children. This
information gap can be reduced by elucidating developmental principles of absorption …

Midazolam (MDZ) is used for sedation in surgical procedures; its clinical effect is related to
its receptor affinity and the dose administered. Therefore, a pharmacokinetic …