A sensitive and selective gas chromatographic mass spectrometric method for the
determination of midazolam and its biologically active metabolite, 1-hydroxymidazolam, in …

Objective: To document maturational changes of the in vivo activity of CYP3A4 in the first
months of life. Methods: The contribution of tramadol (M), O-demethyl tramadol (M1 …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

The extent of decreases in apparent hepatic clearance and intrinsic hepatic clearance of
midazolam (MDZ) after intravenous administration of MDZ with concomitant oral …

Objectives After completing this article, readers should be able to: 1. Summarize the impact
of gestational age, postnatal age, and disease state on drug absorption, distribution …

The magnitude of any metabolic drug–drug interactions (DDIs) depends on fractional
importance of inhibited pathway which may not necessarily be the same in young children …

Purpose Based on recovered metabolite ratios in urine, it has been concluded that
paracetamol glucuronidation may be up-regulated upon multiple dosing. This study …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

PURPOSE. The purpose of this study was to quantify the intestinal metabolism of
midazolam, a CYP P450 substrate, usually used as a probe for the activity of the isoform …

Aim: Large interindividual variability in neonatal propofol clearance is documented which, in
part, can be explained by postmenstrual age (PMA) and postnatal age (PNA). We aimed to …