Fenugreek seed extract regulates human umbilical vein endothelial cell angiogenesis and proliferation via the PI3K/Akt/cyclin D1 pathway

S Safarpour, F Mirzavi, F Rahmani… - Alternatives to …, 2023 - journals.sagepub.com
The significance of angiogenesis in tumour progression has been widely documented.
Hence, the identification of anti-angiogenic agents with fewer common side effects would be …

Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical …

HK Chin, CT Horng, YS Liu, CC Lu… - Oncology …, 2018 - spandidos-publications.com
Anti-angiogenesis is one of the most general clinical obstacles in cancer chemotherapy.
Kaempferol is a flavonoid phytochemical found in many fruits and vegetables. Our previous …

Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades

JH Park, J Yoon, B Park - Phytomedicine, 2016 - Elsevier
Background Pomolic acid (PA), an active triterpenoid from Euscaphis japonica, inhibits the
proliferation of a variety of cancer cells, but the molecular mechanisms of the anti …

12-Deoxyphorbol 13-palmitate inhibit VEGF-induced angiogenesis via suppression of VEGFR-2-signaling pathway

HY Xu, YM Pan, ZW Chen, Y Lin, LH Wang… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: 12-Deoxyphorbol 13-palmitate (G) is one toxic
compound isolated from Euphorbia fischeriana, an Asian spice used for cancer treatment as …

[HTML][HTML] Quercetin Improves the Anti-angiogenic Property of 5-Fluorouracil on the Human Umbilical Vein Endothelial Cells HUVEC Cell Line

A Sanaei, G Mohammadzadeh… - International Journal of …, 2022 - brieflands.com
Background: Angiogenesis provides the oxygen and nutrients needed for metastasis and
tumor growth, so by inhibiting angiogenesis, metastasis to other parts of the body can be …

Quercetin synergistically potentiates the anti-angiogenic effect of 5-fluorouracil on HUVEC cell line

G Mohammadzadeh - 2021 - researchsquare.com
background: Since tumors need oxygen and nutrients to grow and spread, angiogenesis
has an essential role in cancer growth and metastasis. So, inhibition of angiogenesis at the …

Angiogenesis-modulating properties of ethanolic extract of Ferula assa-foetida oleo-gum-resin

N Yazdanipour, M Khorashadizadeh… - Indian Journal of …, 2021 - ijpp.com
Objectives: Angiogenesis has been known to have a critical role in the tumour growth.
Different studies indicated that angiogenesis was stimulated by hypoxia. In the present …

Ferulic acid promotes endothelial cells proliferation through up-regulating cyclin D1 and VEGF

J Wang, Z Yuan, H Zhao, D Ju, Y Chen, X Chen… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Angelicae Sinensis is a well known and
commonly used traditional Chinese herbal medicine with many therapeutic effects such as …

Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells

H Luo, GO Rankin, L Liu, MK Daddysman… - Nutrition and …, 2009 - Taylor & Francis
Ovarian cancer is 1 of the most significant malignancies in the Western world, and the
antiangiogenesis strategy has been postulated for prevention and treatment of ovarian …

[PDF][PDF] Expression of Vascular Endothelial Growth Factor and Anti-Proliferative Activity of Flaxseed Oil Alone and In Combination with Mefenamic Acid in Cell Lines

N Alzubaidy, H Sahib - Iraqi Journal of Pharmaceutical Sciences (P-ISSN …, 2024 - iasj.net
The flaxseed oil contains alpha-linolenic acid, lignans and flavonoids. It possesses anti-
inflammatory, antioxidant, and tumor-suppressive effects. The purpose of this research was …