Background: In the present study, we investigated the anti-angiogenic effects of the ethanol
extract of Ficus carica leave on human umbilical vein endothelial cells (HUVECs). Methods …

Angiogenesis is a process of new blood vessel formation from pre-existing vessels. It is a
normal and vital process in growth and development, as well as in wound healing and in the …

The role of angiogenesis in tumor progression and metastasis formation has been well
recognized. Recent studies have reported that Trigonella foenum-graecum L.(fenugreek) …

Vascular endothelial growth factor (VEGF) is an essential component for angiogenesis, and
hypoxia-inducible factor-1α (HIF-1α), which controls the switch of glycolytic and oxidative …

Our previous study demonstrated that Erxian Decoction (EXD), a traditional Chinese herbal
formula, inhibited angiogenesis in zebrafish embryos. To further investigate the anti …

Epidemiological and animal studies have indicated that consumption of green tea is
associated with a reduced risk of developing certain forms of cancer. However, the inhibitory …

Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to
microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor …

ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic foot ulceration results in high risk of
lower extremity amputation, and represents a significant health care expenditure worldwide …

Cancer is a serious disease with a complex pathogenesis, which threats human life greatly.
Angiogenesis is directly involved in invasion and metastasis of cancer. This study reveals …

Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity;
however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we …