Quercetin Downregulates Cyclooxygenase‐2 Expression and HIF‐1α/VEGF Signaling‐Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm

L Wang, H Wu, L Xiong, X Liu, N Yang… - BioMed Research …, 2020 - Wiley Online Library
Objective. Abdominal aortic aneurysm (AAA) development has been characterized by
increased expression of vascular endothelial growth factor (VEGF), which contributes to …

[HTML][HTML] Kaempferol inhibits angiogenesis by suppressing HIF-1α and VEGFR2 activation via ERK/p38 MAPK and PI3K/Akt/mTOR signaling pathways in endothelial …

GD Kim - Preventive Nutrition and Food Science, 2017 - ncbi.nlm.nih.gov
Kaempferol has been shown to inhibit vascular formation in endothelial cells. However, the
underlying mechanisms are not fully understood. In the present study, we evaluated whether …

[HTML][HTML] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways

P Pratheeshkumar, A Budhraja, YO Son, X Wang… - 2012 - journals.plos.org
Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the
growing tumor to receive oxygen and nutrients. Cancer prevention using natural products …

The epigallocatechin gallate derivative Y6 inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/HIF-1α/VEGF …

ZH Liao, HQ Zhu, YY Chen, RL Chen, LX Fu… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Hypervascularity has been considered as one of the major
features of many solid tumors. Green tea is one of the commonly drink resources in China …

Molecular mechanism of inhibition of the abnormal proliferation of human umbilical vein endothelial cells by hydroxysafflor-yellow A

J Wang, J Wang, X Wang, L Liu, J Hu, X Yu… - Pharmaceutical …, 2016 - Taylor & Francis
Context It has been found that hydroxysafflor-yellow A (HSYA) inhibits angiogenesis and the
proliferation of abnormal human umbilical vein endothelial cells (HUVECs) in our previous …

[HTML][HTML] Fenretinide reduces angiogenesis by downregulating CDH5, FOXM1 and eNOS genes and suppressing microRNA-10b

EI Yücel, M Sahin - Molecular Biology Reports, 2020 - Springer
Angiogenesis is a new vessel formation process that plays a role in various physiological
and pathological conditions. This process is controlled by the balance between pro …

Gambogic acid inhibits angiogenesis through inhibiting PHD2–VHL–HIF-1α pathway

N Lu, H Hui, H Yang, K Zhao, Y Chen, QD You… - European Journal of …, 2013 - Elsevier
Our previous studies revealed that gambogic acid (GA), the major active ingredient of
gamboge, possessed antiangiogenic activities. In this study, we further explored the …

[HTML][HTML] GDF-15 promotes angiogenesis through modulating p53/HIF-1α signaling pathway in hypoxic human umbilical vein endothelial cells

H Song, D Yin, Z Liu - Molecular biology reports, 2012 - Springer
Angiogenesis is an important repair mechanism in response to ischemia/reperfusion (I/R)
injury through increasing blood flow and oxygen supply. Previous studies suggested that …

[HTML][HTML] Evaluation of toxicity and antiangiogenic activity of Murraya koenigii leaf extracts in zebrafish

D Dinesh, DP Nanjappa, N Babu… - Journal of Health …, 2020 - thieme-connect.com
Introduction This study aimed to evaluate the toxicity and the antiangiogenic activity of
Murraya koenigii leaf extracts in zebrafish. Materials and Methods Crude aqueous and …

[HTML][HTML] Quercetin inhibits colorectal cancer cells induced-angiogenesis in both colorectal cancer cell and endothelial cell through downregulation of VEGF-A …

T Uttarawichien, C Kamnerdnond, T Inwisai… - Scientia …, 2021 - mdpi.com
Colorectal cancer (CRC) aggressiveness is caused by cancer angiogenesis which promotes
the cancer growth and metastasis associated with poor prognosis and poor survival. The …