Paired box 6 (Pax6) is considered to be the master control gene for eye development in all
seeing animals studied so far. In vertebrates, it is required not only for lens/retina formation …

Loss of Pax 6 function leads to an eyeless phenotype in both mammals and insects, and
ectopic expression of both the Drosophila and the mouse gene leads to the induction of …

The transcription factor Pax6 is considered the master control gene for eye formation
because (1) it is present within the genomes and retina/lens of all animals with a visual …

Abstract The Drosophila Pax-6 gene eyeless (ey) plays a key role in eye development. Here
we show that Drosophila contains a second Pax-6 gene, twin of eyeless (toy), due to a …

There are two Pax6 genes in Drosophila melanogaster; eyeless (ey) and twin-of-eyeless
(toy), due to a duplication, which most likely occurred in the insect lineage. They encode …

In eye development the tasks of tissue specification and cell proliferation are regulated, in
part, by the Pax6 and Pax6 (5a) proteins respectively. In vertebrates, Pax6 (5a) is generated …

Pax6, a member of the paired-box family of transcription factors, is critical for oculogenesis in
both vertebrates and insects. Identification of potential vertebrate Pax6 targets has been …

Pax-6 genes, known to be essential for eye development, encode an evolutionarily
conserved transcription factor with two DNA-binding domains. To corroborate the …

Abstract Development requires not only the correct specification of organs and cell types in
the right places (pattern), but also the control of their size and shape (growth). Many …

Pax6 genes encode evolutionarily highly conserved transcription factors that are required for
eye and brain development. Despite the characterization of mutations in Pax6 homologs in a …