[HTML][HTML] Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development

A Chêne, S Gangnard, C Dechavanne, S Dechavanne… - NPJ vaccines, 2018 - nature.com
Over 50 million women are exposed to the risk of malaria during pregnancy every year.
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

JYA Doritchamou, JP Renn, B Jenkins, A Mahamar… - Elife, 2022 - elifesciences.org
Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …

Maternal immunization and malaria in pregnancy

PE Duffy - Vaccine, 2003 - Elsevier
Malaria in pregnancy is a major cause of poor outcomes for both mother and fetus, and
malaria-induced low birth weight (LBW) may kill nearly 400,000 African infants each year …

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …

Immunity to malaria during pregnancy: different host, different parasite

PE Duffy - Malaria in Pregnancy, 2001 - taylorfrancis.com
In endemic areas, pregnancy increases susceptibility to P. falciparum and P. vivax, but not P.
malariae, and this susceptibility diminishes with successive pregnancies …

Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

M Hommel, JA Chan, AJ Umbers, C Langer… - Parasites & vectors, 2018 - Springer
Background Malaria in pregnancy is a major cause of poor maternal and infant health, and
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA

VV Pinto, SB Ditlev, KE Jensen, M Resende… - PloS one, 2011 - journals.plos.org
Background In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an
important complication of malaria. The recurrence of malaria in primigravidae women …