The neural and psychological mechanisms of inhibitory control processes were investigated,
focusing on the cortico-basal ganglia circuits in rats and humans. These included …

Background Proactive control is evidenced by top-down cortical modulation of executive
neurocircuitry that inhibits behavior by utilizing advance cues. fMRI research indicates that …

Background Only some individuals who use drugs recreationally eventually develop a
substance use disorder, characterized in part by the rigid engagement in drug foraging …

Disruptions to inhibitory control are believed to contribute to multiple aspects of drug abuse,
from preexisting vulnerability in at-risk individuals, through escalation to dependence, to …

Neuroimaging studies in current cocaine dependent (CD) individuals consistently reveal
cortical hypoactivity across regions of the response inhibition circuit (RIC). Dysregulation of …

Though stimulant drugs such as cocaine are considered highly addictive, some individuals
report recreational use over long periods without developing dependence. Difficulties in …

Background: Dysregulated striatal functioning coupled with executive control deficits arising
from abnormal frontal cortical function are considered key mechanisms in the development …

Drug addiction is characterized by persistent, maladaptive drug-seeking behavior and a
high propensity for relapse after abstinence. Laboratory studies suggest that this phenotype …

Cocaine dependence is associated with increased impulsivity in humans. Both cocaine
dependence and impulsive behavior are under the regulatory control of cortico-striatal …

Preclinical models have consistently demonstrated the importance of the mesocorticolimbic
(MCL) brain reward system in drug dependence, with critical molecular and cellular …