The Hippo pathway plays a key role in development, organ size control and tissue
homeostasis, and its dysregulation contributes to cancer. The LATS tumor suppressor …

Hippo signaling represents a tumor suppressor pathway that regulates organ size and
tumorigenesis through phosphorylation and inhibition of the transcription coactivator YAP …

The Hippo pathway is crucial in organ size control, and its dysregulation contributes to
tumorigenesis. However, upstream signals that regulate the mammalian Hippo pathway …

Organ development is a complex process governed by the interplay of several signalling
pathways that have critical functions in the regulation of cell growth and proliferation. Over …

The Hippo tumor suppressor pathway plays an important role in tissue homeostasis that
ensures development of functional organs at proper size. The YAP transcription coactivator …

Hippo pathway, originally discovered in Drosophila, is responsible for organ size control.
The pathway is conserved in mammals and has a significant role in restraining cancer …

The Hippo pathway plays a crucial role in organ size control and tumor suppression, but its
precise regulation is not fully understood. In this study, we discovered that phosphatidic acid …

Abstract The Hippo (Hpo) tumor suppressor pathway is an evolutionarily conserved
signaling pathway that controls tissue growth and organ size in species ranging from …

The Hippo pathway maintains tissue homeostasis by negatively regulating the oncogenic
transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …