It has already been shown that serotonin can release endocannabinoids at the spinal cord
level, culminating in inhibition of the dorsal horn. At the peripheral level, cannabinoid …

The participation of endocannabinoids in central and peripheral antinociception induced by
several compounds has been shown by our group. In this study, we investigated the effect of …

BACKGROUND: Cannabinoid agonists induce norepinephrine release in central, spinal,
and peripheral sites. Previous studies suggest an interaction between the cannabinoid and …

AIMS: In this study, we investigated whether the opioid system and the nitric oxide pathway
were involved in the peripheral antinociception induced by a cannabinoid receptor agonist …

The purpose of this study was to evaluate the possible contribution of metabotropic
glutamate receptors (mGluRs) to cannabinoid-induced antinociception in the periaqueductal …

The amygdala is a temporal lobe region that is implicated in emotional information
processing. The amygdala also is associated with the processing and modulation of pain …

It has been proposed that cannabinoids act at a Gi protein-coupled receptor to produce
antinociception. One action of Gi-proteins is to decrease intracellular cAMP via inhibition of …

AIMS: The effects of several potassium (K+) channel blockers were studied to determine
which K+ channels are involved in peripheral antinociception induced by the cannabinoid …

BACKGROUND AND PURPOSE Two non‐psychoactive cannabinoids, cannabidiol (CBD)
and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved …

Background and purpose: It has been demonstrated that cannabinoids evoke the release of
endogenous opioids to produce antinociception; however, no information exists regarding …