Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the
midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to …

Hematopoiesis in vertebrate embryos occurs in temporally and spatially overlapping waves
in close proximity to blood vascular endothelial cells. Initially, yolk sac hematopoiesis …

Background: Hematopoietic stem and progenitor cells (HSPCs) are generated de novo in
the embryo in a process termed the endothelial to hematopoietic transition (EHT). EHT is …

In the embryo, the decision to become an endothelial cell (EC) is a bold choice that commits
a cell to the task of generating the blood and lymphatic vascular systems, which form one of …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

Hematopoietic cells arise first in the third week of human ontogeny inside yolk sac
developing blood vessels, then, one week later and independently, from the wall of the …

Several studies have demonstrated that hematopoietic cells originate from endothelium in
early development; however, the phenotypic progression of progenitor cells during human …

The contribution of the different waves and sites of developmental hematopoiesis to fetal
and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial …

During embryogenesis, haematopoietic and endothelial lineages emerge closely in time
and space. It is thought that the first blood and endothelium derive from a common clonal …

The yolk sac is the first site of hematopoiesis during mammalian development. The yolk sac
is also the first site of blood vessel development. Development of the blood islands in the …