ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in
the glymphatic system (the functional waste clearance pathway for the central nervous …

The glymphatic system hypothesis is a concept describing the clearance of waste products
from the brain. The term “glymphatic system” combines the glial and lymphatic systems and …

Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of
the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep …

Background Animal experiments have demonstrated the dependency of cerebrospinal fluid
clearance function on age and sleep, which partially underlay the cognitive decline in the …

Abstract Study Objectives To examine the association between sleep duration trajectories
over 28 years and measures of cognition, gray matter volume, and white matter …

The overall premise of this review is that cerebrospinal fluid (CSF) is transported within a
dedicated peri-vascular network facilitating metabolic waste clearance from the central …

Purpose To analyze the integrity of white matter (WM) tracts in primary insomnia patients
and provide better characterization of abnormal WM integrity and its relationship with …

Objective Aging is a major risk factor for numerous neurological disorders, and the
mechanisms underlying brain aging remain elusive. Recent animal studies demonstrated a …

Objective: Impaired glymphatic waste clearance function during brain aging leads to the
accumulation of metabolic waste and neurotoxic proteins (eg, amyloid-β, tau) which …

Background Glymphatic dysfunction may contribute to the accumulation of Alzheimer's
disease (AD) pathologies. Conversely, AD pathologic change might also cause …