Introduction The second most common form of early‐onset dementia—frontotemporal
dementia (FTD)—is often characterized by the aggregation of the microtubule‐associated …

Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be
caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of …

Mitochondria are responsible for the majority of energy production in energy-intensive
tissues like brain, modulate Ca+ 2 signaling and control initiation of cell death. Because of …

Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases
leading to the generation of lipid peroxides, carbonyl proteins and oxidative DNA damage in …

Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases.
Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar …

Astroglial pathology is seen in various neurodegenerative diseases including frontotemporal
dementia (FTD), which can be caused by mutations in the gene encoding the microtubule …

The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

Neuronal cell loss associated with neurodegeneration has recently been linked to
mitochondrial dysfunction. Electron transport chain defects and reactive oxygen species …

Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a
subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration …

Mitochondrial defects including excess reactive oxygen species (ROS) production and
compromised ATP generation are featured pathology in Alzheimer's disease (AD). Amyloid …