ABSTRACT RNA localization to neuronal dendrites and axons is increasingly recognized as
a significant and widespread mechanism of gene expression control in neurons. High …

Background RNA localization involves cis-motifs that are recognized by RNA-binding
proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA …

The spatial and temporal regulation of gene expression in neurons is an important step in
creating functional and structural neuronal networks. The complexity of neurons require …

Localized translation and the requisite trafficking of the mRNA template play significant roles
in the nervous system including the establishment of dendrites and axons, axon path …

Highlights•∼ 2550 mRNA species are localized in dendrites and/or axons.•The alternative
usage of 3′ UTR isoforms dictates the fate of an mRNA molecule.•Novel multiplexed FISH …

Neurons and glia are highly polarized cells, whose distal cytoplasmic functional subdomains
require specific proteins. Neurons have axonal and dendritic cytoplasmic extensions …

The importance of mRNA localization and localized protein synthesis to spatially modulate
protein levels in distinct subcellular domains has increasingly been recognized in recent …

Highlights•Composition of mRNPs is dynamic across space and time.•mRNPs in dendrites
and axons share common features of diffusion and directed transport.•HMM Bayes approach …

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular
signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in …

Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and
functional compartmentalization. In neurons, localization of specific mRNAs to neurites is …