Key points Hypoxia, a potent activator of the sympathetic nervous system, is known to
increase muscle sympathetic nerve activity (MSNA) to the peripheral vasculature of native …

Lowland-dwelling populations exhibit persistent sympathetic hyperactivity at altitude that
alters vascular function. High-altitude populations, such as Sherpa, have previously …

High-altitude (> 2,500 m) exposure results in increased muscle sympathetic nervous activity
(MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects …

New Findings What is the topic of the review? Sympathoexcitation and sympathetic control
of blood pressure at high altitude. What advances does it highlight? Sustained …

Key points In an anaesthetised animal model, independent stimulation of baroreceptors in
the pulmonary artery elicits reflex sympathoexcitation. In humans, pulmonary arterial …

New Findings What is the central question of this study? High‐altitude hypoxia increases
muscle sympathetic nerve activity (MSNA), but whether intravenous infusion of dopamine, to …

Combined results from different independent studies suggest that acclimatization to high
altitude induces a slowly developing sympathetic activation, even at levels of hypoxia that …

We investigated carotid baroreflex control of vascular resistance in two groups of high‐
altitude natives: healthy subjects (HA) and a group with chronic mountain sickness (CMS), a …

Acute exposure to hypobaric hypoxia at high altitude is reported to cause sympathetic
dominance that may contribute to the pathophysiology of high altitude illnesses. The effect of …

During continued exposure to hypobaric hypoxia in acclimatizing lowlanders increasing
norepinephrine levels indirectly indicate sympathoexcitation, and in a few subjects serial …