The role of oxytocin in parenting and as augmentative pharmacotherapy: critical issues and bold conjectures

MH van IJzendoorn… - Journal of …, 2016 - Wiley Online Library
Despite the sometimes heated debate about the validity of human oxytocin studies,
experimental oxytocin research with intranasal administration is a growing field with …

[HTML][HTML] Oxytocin treatment in pediatric populations

AE Taylor, H Lee, FTA Buisman-Pijlman - Frontiers in behavioral …, 2014 - frontiersin.org
The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors
is well-recognized. Moreover, the use of oxytocin as a facilitator of social and other …

Autism and oxytocin: new developments in translational approaches to therapeutics

JJ Green, E Hollander - Neurotherapeutics, 2010 - Springer
Autism is a neurodevelopmental disorder characterized by dysfunction in three core
symptom domains: speech and communication deficits, repetitive or compulsive behaviors …

Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment

F Naber, MH van IJzendoorn, P Deschamps… - …, 2010 - Elsevier
Recent correlational studies showed that oxytocin is associated with parenting style in
humans as in other mammals. Here the first double-blind, placebo-controlled, within-subject …

A precision medicine approach to oxytocin trials

E Andari, R Hurlemann, LJ Young - Behavioral Pharmacology of …, 2018 - Springer
In this chapter, we introduce a new area of social pharmacology that encompasses the study
of the role of neuromodulators in modulating a wide range of social behaviors and brain …

Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders

H Yamasue - Psychiatry and clinical neurosciences, 2016 - Wiley Online Library
Oxytocin is a potential therapeutic for the core symptoms of autism spectrum disorder (ASD),
which is currently untreatable with pharmacotherapy. Previous clinical trials of a single dose …

Is the efficacy of oxytocin for autism diminished at higher dosages or repeated doses?: potential mechanisms and candidate solutions

H Yamasue - Peptides, 2023 - Elsevier
No approved pharmacological intervention currently exists to address the core symptoms of
autism spectrum disorder, a prevalent neurodevelopmental condition. However, there is a …

[HTML][HTML] Is oxytocin application for autism spectrum disorder evidence-based?

SY Lee, AR Lee, R Hwangbo, J Han… - Experimental …, 2015 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is characterized by persistent deficits within two core
symptom domains: social communication and restricted, repetitive behaviors. Although …

Potential for oxytocin use in children and adolescents with mental illness

E Netherton, D Schatte - Human Psychopharmacology: Clinical …, 2011 - Wiley Online Library
Background Oxytocin, long known for its role in childbirth and breastfeeding, has recently
come under investigation for its psychoactive properties. We investigated its potential for use …

Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies

S John, AV Jaeggi - Autism, 2021 - journals.sagepub.com
The oxytocin system may be different in autistic people, which could explain some of the
deficits in social behavior and cognition associated with autism spectrum disorder. However …