The contents of platelet α‐granules arrive via a number of pathways; some are synthesized
by megakaryocytes (MKs), for example, von Willebrand factor (VWF), whereas others are …

Megakaryocytes (MKs) are rare hematopoietic cells in the adult bone marrow and produce
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …

Background There is interest in deriving megakaryocytes (MKs) from pluripotent stem cells
(iPSC) for biological studies. We previously found that genomic structural integrity and …

Abstract MRG-1 Human induced pluripotent stem cells (hiPSCs) are a promising source of
blood cells, including platelets, for transfusion. However, there remains a need for: 1) a …

Background Platelets are small anucleate cells that circulate in the blood in a resting state
but can be activated by external cues. In case of need, platelets from blood donors can be …

Stem cell–derived platelets have the potential to replace donor platelets for transfusion.
Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture …

Recently, platelet‐derived growth factors present in lysates became an extreme interest in
the field of regenerative medicine such as in wound healing and as substitutes to foetal …

Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …

Several protocols exist for generating megakaryocytes (MKs) and platelets from human
induced pluripotent stem cells (hiPSCs) with limited efficiency. We observed previously that …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …