Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory
bowel disease (IBD). However, the impact of GC signaling on intestinal tumorigenesis …

Background & Aims Inflammatory bowel disease is commonly treated by administration of
glucocorticoids. While the importance of intestinal epithelial cells for the pathogenesis of this …

Metastasis is regarded as the fatal hallmark for colon cancer, but molecular mechanisms
responsible for it have remained poorly defined. Glucocorticoid receptor (GR) within the …

The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are
unclear. In this study, we investigated the therapeutic roles of glucocorticoids in acute …

TNF is an important mediator in numerous inflammatory diseases, eg, in inflammatory bowel
diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares …

Corticosteroid treatment (CST) failure is associated with poor outcomes for patients with
gastrointestinal (GI) graft-versus-host disease (GVHD). CST is intended to target the immune …

Control of tumour development and growth by the immune system critically defines patient
fate and survival. What regulates the escape of colorectal tumours from destruction by the …

Glucocorticoids are effective to treat lymphoma and leukemia. Their effect in colon cancer
remains far from clear. Here, we found that glucocorticoid receptor (GR) α protein level was …

The aim of this study was to examine glucocorticoid receptor (GR) immunohistochemical
expression in colon cancer histopathological specimens and to correlate it with …

Background and Purpose Glucocorticoids are the first line treatment for the flare‐ups of
inflammatory bowel disease, but they have significant limitations. The objective of this study …