Abstract Development of peripheral nervous system (PNS) myelin involves a coordinated
series of events between growing axons and the Schwann cell (SC) progenitors that will …

Myelination provides extrinsic trophic signals that influence normal maturation and long-term
survival of axons. The extent of axonal involvement in diseases affecting myelin or myelin …

The formation of myelin in the central nervous system is a multi-step process that involves
coordinated cell–cell interactions and dramatic changes in plasma membrane architecture …

Myelin is a multilamellar cell membrane around axons and is essential for fast saltatory
conduction and maintenance of axonal integrity and survival. Congenital and acquired …

In multiple sclerosis (MS), axons of the central nervous system lose their myelin sheaths,
and there is also death of oligodendrocytes. Although some demyelinated axons rebuild …

Myelin sheaths, by supporting axonal integrity and allowing rapid saltatory impulse
conduction, are of fundamental importance for neuronal function. In response to …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Axonal degeneration is a pivotal feature of many neurodegenerative conditions and
substantially accounts for neurological morbidity. A widely used experimental model to study …

Axon loss and neurodegeneration constitute clinically debilitating sequelae in demyelinating
diseases such as multiple sclerosis, but the underlying mechanisms of secondary …

Axons are the anatomical link between neuronal cell bodies and their target organs, and
thus axonal degeneration is the pathological substrate that underlies neurological …