Orthodontic force induces nerve injury-like transcriptomic changes driven by TRPV1-expressing afferents in mouse trigeminal ganglia

S Wang, MK Chung - Molecular Pain, 2020 - journals.sagepub.com
Orthodontic force produces mechanical irritation and localized inflammation in the
periodontium, which causes pain in most patients. Nocifensive behaviors resulting from …

[HTML][HTML] TRPV1 and TRPV1-expressing nociceptors mediate orofacial pain behaviors in a mouse model of orthodontic tooth movement

S Wang, M Kim, Z Ali, K Ong, EK Pae… - Frontiers in …, 2019 - frontiersin.org
Orthodontic force produces mechanical irritation and inflammation in the periodontium,
which is inevitably accompanied by pain. Despite its prevalence, treatment of orthodontic …

Varied temporal expression patterns of trigeminal TRPA1 and TRPV1 and the neuropeptide CGRP during orthodontic force-induced pain

P Thammanichanon, A Kaewpitak, T Binlateh… - Archives of Oral …, 2021 - Elsevier
Objective The aim of this study was to quantify the temporal changes in inflammation and
TRPA1, TRPV1 and CGRP expression in the trigeminal ganglion during force-induced …

[HTML][HTML] Nociceptor mechanisms underlying pain and bone remodeling via orthodontic forces: toward no pain, big gain

S Wang, CC Ko, MK Chung - Frontiers in Pain Research, 2024 - frontiersin.org
Orthodontic forces are strongly associated with pain, the primary complaint among patients
wearing orthodontic braces. Compared to other side effects of orthodontic treatment …

Blocking of TRPV-1 in the parodontium relieves orthodontic pain by inhibiting the expression of TRPV-1 in the trigeminal ganglion during experimental tooth …

Y Gao, Y Liu, K Zhu, Z Zhang, H Qiao, Z Lu, T Zhong… - Neuroscience …, 2016 - Elsevier
Orthodontic pain has confused the orthodontics for a long time, and recent research
demonstrated that transient receptor potential vanilloid type 1 (TRPV1) had crucial functions …

Orthodontic force-induced oxidative stress in the periodontal tissue and dental pulp elicits nociception via activation/sensitization of TRPA1 on nociceptive fibers

A Morii, Y Miyamura, MI Sago, M Mizuhara… - Free radical Biology and …, 2020 - Elsevier
Orthodontic patients complain of pain for the first few days after insertion of appliances.
Mechanical force has been reported to produce oxidants in periodontal ligament (PDL) cells …

Increased expression of TRPV1 in the trigeminal ganglion is involved in orofacial pain during experimental tooth movement in rats

H Qiao, YN Gao, C Zhang… - European Journal of Oral …, 2015 - Wiley Online Library
To investigate whether transient receptor potential vanilloid type 1 (TRPV 1) is involved in
pain induced by experimental tooth movement, experiments were performed in male S …

[HTML][HTML] Differential Changes in TRPV1 expression after trigeminal sensory nerve injury

HY Kim, CK Park, IH Cho, SJ Jung, JS Kim, SB Oh - The Journal of Pain, 2008 - Elsevier
We have recently demonstrated that inferior alveolar nerve and mental nerve (branches of
the mandibular nerve) injury from rats serves as a valid trigeminal neuropathic pain model …

Occlusal trauma induces neuroimmune crosstalk for a pain state

HB Abdalla, MH Napimoga… - Journal of Dental …, 2022 - journals.sagepub.com
Temporomandibular joint (TMJ) disorder caused by occlusal trauma is one of the most
controversial topics in dentistry. Experimental traumatic occlusion (ETO) induced by metal …

Neuronal plasticity of trigeminal ganglia in mice following nerve injury

R Lynds, C Lyu, GW Lyu, XQ Shi, A Rosén… - Journal of pain …, 2017 - Taylor & Francis
Background Nerve injury may induce neuropathic pain. In studying the mechanisms of
orofacial neuropathic pain, attention has been paid to the plastic changes that occur in the …