Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
H Bazzazi, AS Popel - PLoS computational biology, 2017 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a powerful regulator of neovascularization.
VEGF binding to its cognate receptor, VEGFR2, activates a number of signaling pathways …
VEGF binding to its cognate receptor, VEGFR2, activates a number of signaling pathways …
Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking
WH Tan, AS Popel, F Mac Gabhann - Cellular signalling, 2013 - Elsevier
Abstract Vascular Endothelial Growth Factor (VEGF) signal transduction is central to
angiogenesis in development and in pathological conditions such as cancer, retinopathy …
angiogenesis in development and in pathological conditions such as cancer, retinopathy …
Computational model of Gab1/2-dependent VEGFR2 pathway to Akt activation
WH Tan, AS Popel, F Mac Gabhann - PloS one, 2013 - journals.plos.org
Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in
development and in pathological conditions such as cancer, retinopathy and ischemic …
development and in pathological conditions such as cancer, retinopathy and ischemic …
Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to …
Angiogenesis is a critical step in tumor growth, development, and invasion. Nascent tumor
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways
JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …
Site-specific phosphorylation of VEGFR2 is mediated by receptor trafficking: insights from a computational model
LW Clegg, F Mac Gabhann - PLoS computational biology, 2015 - journals.plos.org
Matrix-binding isoforms and non-matrix-binding isoforms of vascular endothelial growth
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …
ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Background Angiogenesis plays an important role in the survival of tissues, as blood vessels
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors
Background Angiogenesis is important in physiological and pathological conditions, as
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells
S Sarabipour, K Kinghorn, KM Quigley… - PLOS Computational …, 2024 - journals.plos.org
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and …
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …