Large-scale simulations of cellular signaling processes
JH Miller, F Zheng - Parallel Computing, 2004 - Elsevier
A database of rate constants and related quantities has been assembled by [Nature Biotech.
20 (2002) 370] for intracellular signaling downstream of the epidermal growth factor receptor …
20 (2002) 370] for intracellular signaling downstream of the epidermal growth factor receptor …
Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti-and pro-angiogenic therapies
M Shibuya - Genes & cancer, 2011 - journals.sagepub.com
The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown
to play major roles not only in physiological but also in most pathological angiogenesis …
to play major roles not only in physiological but also in most pathological angiogenesis …
Vegf-mediated signal transduction in tumor angiogenesis
L Napione, M Alvaro, F Bussolino - Physiol Pathol Angiogenes …, 2017 - books.google.com
The vascular endothelial growth factor-A (VEGF) plays a crucial role in tumor angiogenesis.
Through its primary receptor VEGFR-2, VEGF exerts the activity of a multitasking cytokine …
Through its primary receptor VEGFR-2, VEGF exerts the activity of a multitasking cytokine …
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …
important mediator of vascular patterning. Previous experimental studies in the mouse …
From pathway to population–a multiscale model of juxtacrine EGFR-MAPK signalling
Background Most mathematical models of biochemical pathways consider either signalling
events that take place within a single cell in isolation, or an'average'cell which is considered …
events that take place within a single cell in isolation, or an'average'cell which is considered …
Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis
Abstract Vascular Endothelial Growth Factor-A (VEGFA) signaling is crucial to the cellular
processes involved in angiogenesis. Previously, we assembled a network of molecular …
processes involved in angiogenesis. Previously, we assembled a network of molecular …
Angiogenic networks in tumors—insights via mathematical modeling
Angiogenesis, the formation of a network of blood vessels, is a vital process in the growth of
solid tumors as it delivers required nutrients and oxygen. Prior medical studies assert that …
solid tumors as it delivers required nutrients and oxygen. Prior medical studies assert that …
A network model to explore the effect of the micro-environment on endothelial cell behavior during angiogenesis
Angiogenesis is an important adaptation mechanism of the blood vessels to the changing
requirements of the body during development, aging, and wound healing. Angiogenesis …
requirements of the body during development, aging, and wound healing. Angiogenesis …
Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway
The epidermal growth factor receptor (EGFR) activated extracellular-signal regulated kinase
(ERK) pathway is a central cell signalling pathway that mediates many biological responses …
(ERK) pathway is a central cell signalling pathway that mediates many biological responses …
Sp3‐mediated VEGF regulation is dependent on phosphorylation by extra‐cellular signals regulated kinases (Erk)
G Pagès - Journal of cellular physiology, 2007 - Wiley Online Library
We have previously demonstrated that phosphorylation by Erk of Sp1 was essential for its
full activity in the context of the VEGF promoter. Here, we show that Sp3, which, as Sp1 …
full activity in the context of the VEGF promoter. Here, we show that Sp3, which, as Sp1 …