Large-scale simulations of cellular signaling processes
JH Miller, F Zheng - Parallel Computing, 2004 - Elsevier
A database of rate constants and related quantities has been assembled by [Nature Biotech.
20 (2002) 370] for intracellular signaling downstream of the epidermal growth factor receptor …
20 (2002) 370] for intracellular signaling downstream of the epidermal growth factor receptor …
Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis
Abstract Vascular Endothelial Growth Factor-A (VEGFA) signaling is crucial to the cellular
processes involved in angiogenesis. Previously, we assembled a network of molecular …
processes involved in angiogenesis. Previously, we assembled a network of molecular …
Angiogenic networks in tumors—insights via mathematical modeling
Angiogenesis, the formation of a network of blood vessels, is a vital process in the growth of
solid tumors as it delivers required nutrients and oxygen. Prior medical studies assert that …
solid tumors as it delivers required nutrients and oxygen. Prior medical studies assert that …
A hybrid multiscale model for investigating tumor angiogenesis and its response to cell-based therapy
M Hendrata, J Sudiono - In Silico Biology, 2019 - content.iospress.com
Angiogenesis, a formation of blood vessels from an existing vasculature, plays a key role in
tumor growth and its progression into cancer. The lining of blood vessels consists of …
tumor growth and its progression into cancer. The lining of blood vessels consists of …
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …
important mediator of vascular patterning. Previous experimental studies in the mouse …
Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Mathematical models of biochemical reaction networks are an important and emerging tool
for the study of cell signaling networks involved in disease processes. One promising …
for the study of cell signaling networks involved in disease processes. One promising …
Network quantification of EGFR signaling unveils potential for targeted combination therapy
B Klinger, A Sieber, R Fritsche‐Guenther… - Molecular systems …, 2013 - embopress.org
The epidermal growth factor receptor (EGFR) signaling network is activated in most solid
tumors, and small‐molecule drugs targeting this network are increasingly available …
tumors, and small‐molecule drugs targeting this network are increasingly available …
Vegf-mediated signal transduction in tumor angiogenesis
L Napione, M Alvaro, F Bussolino - Physiol Pathol Angiogenes …, 2017 - books.google.com
The vascular endothelial growth factor-A (VEGF) plays a crucial role in tumor angiogenesis.
Through its primary receptor VEGFR-2, VEGF exerts the activity of a multitasking cytokine …
Through its primary receptor VEGFR-2, VEGF exerts the activity of a multitasking cytokine …
From pathway to population–a multiscale model of juxtacrine EGFR-MAPK signalling
Background Most mathematical models of biochemical pathways consider either signalling
events that take place within a single cell in isolation, or an'average'cell which is considered …
events that take place within a single cell in isolation, or an'average'cell which is considered …
[HTML][HTML] Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium
To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial
Erk2 knockout in adult Erk1−/− mice. This resulted in a rapid onset of hypertension, a …
Erk2 knockout in adult Erk1−/− mice. This resulted in a rapid onset of hypertension, a …