Preservation of the excitability of spiral ganglion neurons (SGN) may contribute to an
improved speech perception after cochlear implantation. Thus, the application of exogenous …

In mammals, degeneration of peripheral auditory neurons constitutes one of the main
causes of sensorineural hearing loss. Unfortunately, to date, pharmacological interventions …

Neurotrophins (NTs) play essential roles in the development and survival of neurons in PNS
and CNS. In the cochlea, NTs [eg, NT-3, brain-derived neurotrophic factor (BDNF)] are …

A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in
people with severe sensorineural hearing loss (SNHL). However, these neurons …

Enhanced spiral ganglion neuron (SGN) survival and regeneration of peripheral axons
following deafness will likely enhance the efficacy of cochlear implants. Overexpression of …

Most sensorineural hearing loss cases occur as a result of hair cell loss, which results in
secondary degeneration of spiral ganglion neurons (SGNs). Substantial loss of SGNs …

Background: The benefit of cochlea implant (CI) is depending, among other factors, on the
number of surviving spiral ganglion neurons (SGN). Studies have shown that the external …

Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual
degeneration following loss of the sensory epithelium in deafness. The preservation of a …

Hair cell loss, the most common cause of deafness, is often associated with auditory nerve
degeneration. Our goal was to determine the influence of combined ciliary-derived …

Severe hearing loss or deafness is often caused by cochlear hair cell loss, and can be
mitigated by a cochlear implant (CI). CIs target the auditory nerve, consisting of spiral …