Background: Survival and integrity of the spiral ganglion is vital for hearing in background
noise and for optimal functioning of cochlear implants. Numerous studies have …

Hearing loss is a common sensory disorder that has been a serious concern globally. It is
recently estimated that around 466 million people worldwide have disabling hearing loss …

Abstract Objectives/Hypothesis Auditory dysfunction following ototoxic insult results from
loss of cochlear hair cells. Secondary degeneration of auditory neurons ensues from …

Auditory neurons connect the sensory hair cells from the inner ear to the brainstem. These
bipolar neurons are relevant targets for pharmacological intervention aiming at protecting or …

Background The efficacy of cochlear implant performance depends, among many other
factors, on the number of excitable spiral ganglion cells (SGCs) and the nerve-electrode …

The development and maintenance of spiral ganglion neurons (SGNs) appears to be
supported by both neural activity and neurotrophins. Removal of this support leads to their …

Background Phosphatidylinositol 3-kinase (PI3K) is considered to be an important enzyme
in cell signaling, mediating certain aspects of neurotrophin signals from the cell surface …

Acoustic trauma, aging, genetic defects or ototoxic drugs are causes for sensorineural
hearing loss involving sensory hair cell death and secondary degeneration of spiral …

Nerve growth factor (NGF) is a neurotrophic factor that modulates survival and differentiation
of neural stem cells (NSCs). We investigated the function of NGF in promoting growth and …

Aminoglycoside antibiotics induce sensorineural hearing loss by destroying hair cells of the
organ of Corti, causing progressive secondary degeneration of primary auditory or spiral …