Nattokinase Encapsulated Nanomedicine for Targeted Thrombolysis: Development, Improved in Vivo Thrombolytic Effects, and Ultrasound/Photoacoustic Imaging
Nattokinase (NK), a potent thrombolytic enzyme that dissolves blood clots, is highly used in
the treatment of cardiovascular disorders. However, its effective delivery remains demanding …
the treatment of cardiovascular disorders. However, its effective delivery remains demanding …
Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis
Thrombus-related diseases have a high mortality rate and are seriously threatening human
life and health. Nattokinase (NK), which has a strong thrombolytic effect, can treat thrombotic …
life and health. Nattokinase (NK), which has a strong thrombolytic effect, can treat thrombotic …
Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis
C Wu, C Gao, S Lü, X Xu, N Wen… - Journal of Biomedical …, 2018 - Wiley Online Library
Thrombotic disease has become one of the leading causes of mortality among humans
globally. Nattokinase (NK), a novel thrombolytic agent, has attracted the attention of …
globally. Nattokinase (NK), a novel thrombolytic agent, has attracted the attention of …
Preparation and property studies of enteric-soluble oral nattokinase microcapsules with halloysite nanotubes
W Hu, M Zhou, L Hu, K Huang, S Zhao… - … Journal of Polymeric …, 2024 - Taylor & Francis
Abstract Eudragit L100-55-halloysite nanotubes (EL100-55, HNTs) nanocomposite
microcapsules were introduced to release nattokinase (NK) and avoid the limitations of oral …
microcapsules were introduced to release nattokinase (NK) and avoid the limitations of oral …
Downstream processing, formulation development and antithrombotic evaluation of microbial nattokinase
The present research work describes the downstreaming of nattokinase (NK) produced by
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …
Non-covalent modification of thrombolytic agent nattokinase: simultaneous improvement of fibrinolysis activity and enzymatic stability
C Chen, H Duan, C Gao, M Liu, Y Wei, X Zhang, Z Liu - RSC Advances, 2014 - pubs.rsc.org
Cardiovascular disease (CVD) has become the leading cause of death globally. Nattokinase
(NK), as a novel thrombolytic agent, has gained more and more attention. However, NK is …
(NK), as a novel thrombolytic agent, has gained more and more attention. However, NK is …
A nattokinase carrier bonding with polyglutamic acid peptide dendrimer for improved thrombolysis
M Huang, S Lü, Y Ji, Z Wang, SF Zhang… - Polymers for …, 2019 - Wiley Online Library
Thrombosis has become one of the major diseases harmful to human health. The new‐
generation thrombolytic drug nattokinase (NK) has been used in the treatment of thrombosis …
generation thrombolytic drug nattokinase (NK) has been used in the treatment of thrombosis …
Synthesis of mesoporous silica/polyglutamic acid peptide dendrimer with dual targeting and its application in dissolving thrombus
M Huang, SF Zhang, S Lü, T Qi, J Yan… - … Research Part A, 2019 - Wiley Online Library
With the frequent occurrence of thrombus diseases, thrombus has become a factor
endangering human health. Nattokinase (NK) is a new generation of thrombolytic drug with …
endangering human health. Nattokinase (NK) is a new generation of thrombolytic drug with …
Synthesis of PEGylated polyglutamic acid peptide dendrimer and its application in dissolving thrombus
SF Zhang, C Gao, S Lü, J He, M Liu, C Wu, Y Liu… - Colloids and Surfaces B …, 2017 - Elsevier
Nattokinase (NK) has been used as a new generation thrombolytic drug, due to its high
safety, low cost and low side effects. However, it is sensitive to external environment and …
safety, low cost and low side effects. However, it is sensitive to external environment and …
Chitosan/casein based microparticles with a bilayer shell–core structure for oral delivery of nattokinase
X Zhang, X Lyu, Y Tong, J Wang, J Ye, R Yang - Food & function, 2020 - pubs.rsc.org
Nattokinase is a thrombolytic enzyme obtained from Japanese traditional food natto for
prevention and cure of thrombosis-related cardiovascular diseases. However, the …
prevention and cure of thrombosis-related cardiovascular diseases. However, the …