In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

Conformational flexibility plays a critical role in enzyme function and regulation.
Conformational changes, which can occur on multiple length and time scales, facilitate, for …

Conspectus Because living organisms are in constant motion, the word “dynamics” can hold
many meanings to biologists. Here we focus specifically on the conformational changes that …

From a chemical point of view, enzymes are by far the most structurally complex and
functionally sophisticated molecules known. This is perhaps not surprising, once one …

Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …

Enzymatic reactions and related protein conformational dynamics are complex and
inhomogeneous, playing crucial roles in biological functions. The relationship between …

Highlights•Loops and channels are both promising dynamic engineering targets for altered
enzymatic properties.•The relevance of loop dynamics in engineering studies highlights to …

Even after a century of investigation, our understanding of how enzymes work remains far
from complete. In particular, several factors that enable enzymes to achieve high catalytic …

The functional cycle of many proteins involves large-scale motions of domains and subunits.
The relation between conformational dynamics and the chemical steps of enzymes remains …

Recent data increasingly reveal that conformational dynamics are indispensable to enzyme
function throughout the catalytic cycle, in substrate recruiting, chemical transformation, and …