Abstract Extracellular Hsp70 (eHsp70) can activate immune cells via Toll-like receptors
(TLR) 2 and 4, and induce cytokine synthesis. The aim of this study was to explore …

Abstract Extracellular Hsp70 (eHsp70) can act as pro-inflammatory mediator and is elevated
in blood of chronic obstructive pulmonary disease (COPD) patients. Most of those patients …

New Findings What is the central question of this study? Does extracellular heat shock
protein 70 (eHsp70) alter cigarette smoke extract (CSE)‐induced inflammatory responses in …

HSP60 has been implicated in chronic inflammatory disease pathogenesis, including
chronic obstructive pulmonary disease (COPD), but the mechanisms by which this …

Summary Extracellular Hsp70 (eHsp70) exerts its biological actions via Toll‐like receptors 2
and 4, and is increased in sera of chronic obstructive pulmonary disease (COPD) patients …

Background Heat shock protein 70 (HSP70) plays a critical role in the process of
inflammation and innate immunity response under environmental stress. Objectives This …

Chronic obstructive pulmonary disease (COPD) is characterized by increased cellular stress
and inflammation. Heat shock protein 60 (HSP60) is a highly conserved stress protein that …

Background It is increasingly clear that some heat shock proteins (Hsps) play a role in
inflammation. Here, we report results showing participation of Hsp60 in the pathogenesis of …

Background Chronic obstructive pulmonary disease (COPD) is an inflammatory disease
mainly caused by smoking. Cigarette smoke damages airway epithelium and activates lung …

Heat shock proteins are generally regarded as intracellular proteins acting as molecular
chaperones; however, Hsp72 is also detected in the extracellular compartment. Hsp72 has …