Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …

Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …

Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …

Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum
parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite …

Pregnancy-associated malaria is caused by Plasmodium falciparum malaria parasites
binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is …

Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …

Infection with Plasmodium falciparum during pregnancy is one of the major causes of
malaria related morbidity and mortality in newborn and mothers. The complications of …

Placental malaria can have severe consequences for both mother and child and effective
vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through …

People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …

The Plasmodium falciparum multigene var family codes for approximately 50 variant
adhesive proteins expressed in a mutually exclusive manner at the surface of infected red …