Emerging kinase inhibitors for the treatment of pancreatic ductal adenocarcinoma

U Rudloff - Expert opinion on emerging drugs, 2022 - Taylor & Francis
Introduction Pancreatic cancer is one of the deadliest solid organ cancers. In the absence of
specific warning symptoms pancreatic cancer is diagnosed notoriously late. Current …

Molecular-based and alternative therapies for pancreatic cancer: Looking “out of the box”

R Tholey, JA Sawicki, JR Brody - The Cancer Journal, 2012 - journals.lww.com
The current treatment options for pancreatic ductal adenocarcinoma fall exceedingly short of
a cure, providing a sobering 5-year survival rate of only 5% for all patients, and the disease …

Emerging protein kinase inhibitors for treating pancreatic cancer

J Furuse, F Nagashima - Expert opinion on emerging drugs, 2017 - Taylor & Francis
Introduction: Pancreatic cancer, the incidence and mortality of which are increasing around
the world, has the most dismal prognosis among the commonly encountered cancers …

[HTML][HTML] Recent advances in the treatment of pancreatic cancer

MT Roth, DB Cardin, JD Berlin - F1000Research, 2020 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma is one of the deadliest solid tumor malignancies and is
projected to become a leading cause of cancer-related death in coming years. Improving …

Novel targets in pancreatic cancer therapy-current status and ongoing translational efforts

S Bisht, G Feldmann - Oncology Research and Treatment, 2018 - karger.com
Pancreatic ductal adenocarcinoma (PDAC, pancreatic cancer) carries one of the poorest
overall prognoses of all human malignancies known to date. Despite the introduction of …

[HTML][HTML] Targeted therapies for pancreatic cancer: overview of current treatments and new opportunities for personalized oncology

C Leroux, G Konstantinidou - Cancers, 2021 - mdpi.com
Simple Summary The lack of early diagnosis and the absence of suitable biomarkers
coupled with resistance to available therapeutic options render pancreatic cancer one of the …

The trend toward more target therapy in pancreatic ductal adenocarcinoma

C Deiana, M Agostini, G Brandi… - Expert Review of …, 2024 - Taylor & Francis
Introduction Despite the considerable progress made in cancer treatment through the
development of target therapies, pancreatic ductal adenocarcinoma (PDAC) continues to …

[HTML][HTML] Update on current pancreatic treatments: from molecular pathways to treatment

K Sapalidis, C Kosmidis, V Funtanidou… - Journal of …, 2019 - ncbi.nlm.nih.gov
Pancreatic cancer is still diagnosed at a late stage although we have novel diagnostic tools.
Pancreatic cancer chemotherapy treatment resistance is observed and therefore novel …

Advanced pancreatic carcinoma: current treatment and future challenges

A Stathis, MJ Moore - Nature reviews Clinical oncology, 2010 - nature.com
Pancreatic adenocarcinoma is the most lethal of the solid tumors and the fourth leading
cause of cancer-related death in North America. Most patients present with locally advanced …

Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

EG Chiorean, AL Coveler - Drug design, development and therapy, 2015 - Taylor & Francis
Pancreatic cancer is the fourth leading cause of cancer death in the US and is expected to
become the second leading cause of cancer-related deaths in the next decade. Despite 5 …