Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice
T Pearson, TG Markees, DV Serreze… - The Journal of …, 2003 - journals.aai.org
Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and
recurrent autoimmunity. This has been achieved with systemic immunosuppression, but …
recurrent autoimmunity. This has been achieved with systemic immunosuppression, but …
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
T Pearson, TG Markees, DV Serreze… - Annals of the New …, 2003 - Wiley Online Library
Recent advances in islet transplantation have enabled physicians to cure type 1
autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side …
autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side …
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction
T Pearson, TG Markees, LS Wicker, DV Serreze… - Diabetes, 2003 - Am Diabetes Assoc
The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model
involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD …
involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD …
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice
EJ Gordon, LS Wicker, LB Peterson, DV Serreze… - Diabetes, 2005 - Am Diabetes Assoc
Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6
mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune …
mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune …
Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of Idd3
T Pearson, P Weiser, TG Markees, DV Serreze… - Diabetes, 2004 - Am Diabetes Assoc
NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance
to transplantation tolerance induction. These two phenotypes are genetically separable …
to transplantation tolerance induction. These two phenotypes are genetically separable …
NOD mice have a generalized defect in their response to transplantation tolerance induction.
TG Markees, DV Serreze, NE Phillips, CH Sorli… - Diabetes, 1999 - Am Diabetes Assoc
A protocol consisting of a single donor-specific transfusion (DST) plus a brief course of anti-
CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft …
CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft …
Nondepleting anti-CD4 and soluble interleukin-1 receptor prevent autoimmune destruction of syngeneic islet grafts in diabetic NOD mice1
M Drage, P Zaccone, JM Phillips, F Nicoletti… - …, 2002 - journals.lww.com
Background. Successful islet transplantation in type 1 diabetes requires tolerance induction
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …
Resistance to anti‐CD45RB‐induced tolerance in NOD mice: mechanisms involved
DJ Moore, X Huang, MK Lee IV, MM Lian… - Transplant …, 2004 - Wiley Online Library
While great advances have been made in the success of islet transplantation to cure
autoimmune diabetes, this protocol remains limited by our inability to induce donor‐specific …
autoimmune diabetes, this protocol remains limited by our inability to induce donor‐specific …
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic …
L Makhlouf, ST Grey, V Dong, E Csizmadia… - …, 2004 - journals.lww.com
Background. The prevention of recurrent autoimmunity is a prerequisite for successful islet
transplantation in patients with type I diabetes. Therapies effective in preserving pancreatic β …
transplantation in patients with type I diabetes. Therapies effective in preserving pancreatic β …
Prolonged islet allograft survival in diabetic NOD mice by targeting CD45RB and CD154
Clinical islet transplantation is a successful procedure that can improve the quality of life in
recipients with diabetes. A drawback of the procedure is the need for chronic administration …
recipients with diabetes. A drawback of the procedure is the need for chronic administration …