Background Mouse models of heart disease are extensively employed. The
echocardiographic characterization of contractile function is usually focused on systolic …

Murine models have been utilized with increasing frequency mainly due to availability of
genetically engineered models. With advancement in high spatial and temporal resolution …

Ventricular dysfunction remains a hallmark of most cardiac disease. The mouse has become
an essential model system for cardiovascular biology, and echocardiography an established …

Transgenic mice displaying abnormalities in cardiac development and function represent a
powerful new tool for understanding molecular mechanisms underlying normal …

Doppler-echocardiographic assessment of cardiovascular structure and function in murine
models has developed into one of the most commonly used non-invasive techniques during …

Left ventricular diastolic dysfunction leads to heart failure with preserved ejection fraction, an
increasingly prevalent condition largely driven by modern day lifestyle risk factors. As heart …

Background Although chronic pressure overload may progress to left ventricular (LV) failure,
the pathophysiology of this transition is not well understood. In addition, the effects of chronic …

Rats and mice are the predominant experimental species in cardiovascular research due to
the widespread availability of genetic and transgenic rodent models of heart disease …

Background Transthoracic echocardiography (M-mode and Doppler) offers a noninvasive
approach for in vivo evaluation of the mouse heart. The present study examines its …

Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In
human subjects, increased left atrial size is a powerful predictor of mortality and adverse …