Astrocyte gliotransmission in the regulation of systemic metabolism

CDB Murat, C García-Cáceres - Metabolites, 2021 - mdpi.com
Normal brain function highly relies on the appropriate functioning of astrocytes. These glial
cells are strategically situated between blood vessels and neurons, provide significant …

Brain metabolic sensing and metabolic signaling at the level of an astrocyte

N Marina, E Turovsky, IN Christie, PS Hosford… - Glia, 2018 - Wiley Online Library
Astrocytes support neuronal function by providing essential structural and nutritional
support, neurotransmitter trafficking and recycling and may also contribute to brain …

The astrocyte: metabolic hub of the brain

LF Barros, S Schirmeier… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Astrocytic metabolism has taken center stage. Interposed between the neuron and the
vasculature, astrocytes exert control over the fluxes of energy and building blocks required …

Astrocyte-neuron metabolic cooperation shapes brain activity

G Bonvento, JP Bolaños - Cell metabolism, 2021 - cell.com
The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism

JA Chowen, LM Frago… - Journal of …, 2019 - Wiley Online Library
The role of glial cells, including astrocytes, in metabolic control has received increasing
attention in recent years. Although the original interest in these macroglial cells was a result …

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

S Nampoothiri, R Nogueiras, M Schwaninger… - Nature …, 2022 - nature.com
Communication between the periphery and the brain is key for maintaining energy
homeostasis. To do so, peripheral signals from the circulation reach the brain via the …

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

C García-Cáceres, E Balland, V Prevot, S Luquet… - Nature …, 2019 - nature.com
Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

Astrocyte involvement in metabolic regulation and disease

M Naveed, K Smedlund, QG Zhou, W Cai… - Trends in Endocrinology & …, 2024 - cell.com
Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety
of brain parameters including neuronal energy metabolism. Exciting recent studies have …

A role for astrocytes in the central control of metabolism

CX Yi, KM Habegger, JA Chowen, J Stern… - …, 2011 - karger.com
Over the last decades, the negative health consequences of obesity have triggered massive
searches for the cause of–and potential solutions for–the excessive mismatch between …

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

JA Chowen, P Argente-Arizón, A Freire-Regatillo… - Progress in …, 2016 - Elsevier
The hypothalamus is crucial in the regulation of homeostatic functions in mammals, with the
disruption of hypothalamic circuits contributing to chronic conditions such as obesity …