[HTML][HTML] Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System
F Scheffel, T Knuschke, L Otto, S Kollenda, V Sokolova… - Vaccines, 2020 - mdpi.com
The ability of vaccines to induce T cell responses is crucial for preventing diseases caused
by viruses. Nanoparticles (NPs) are considered to be efficient tools for the initiation of potent …
by viruses. Nanoparticles (NPs) are considered to be efficient tools for the initiation of potent …
The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization
T Knuschke, M Epple… - Human Vaccines & …, 2014 - Taylor & Francis
Potent vaccines require the ability to effectively induce immune responses. Especially for the
control of infectious diseases with intracellular pathogens, like viruses or bacteria, potent T …
control of infectious diseases with intracellular pathogens, like viruses or bacteria, potent T …
Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection
T Knuschke, V Sokolova, O Rotan… - The Journal of …, 2013 - journals.aai.org
The ability of vaccines to induce T cell responses is crucial for preventing diseases caused
by viruses or bacteria. Nanoparticles (NPs) are considered an efficient tool for inducing …
by viruses or bacteria. Nanoparticles (NPs) are considered an efficient tool for inducing …
The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell …
Dendritic cells (DCs) are potent antigen-presenting cells that possess the ability to stimulate
naïve T cells. Antigen presentation by mature (activated) DCs is a prerequisite for the …
naïve T cells. Antigen presentation by mature (activated) DCs is a prerequisite for the …
Calcium phosphate nanoparticles for transcutaneous vaccine delivery
P Sahdev, S Podaralla, RS Kaushik… - Journal of biomedical …, 2013 - ingentaconnect.com
The main objective of this study was to investigate the potential of calcium phosphate (CAP)
nanoparticles for transcutaneous vaccine delivery. CAP nanoparticles were prepared by …
nanoparticles for transcutaneous vaccine delivery. CAP nanoparticles were prepared by …
[HTML][HTML] The potential of calcium phosphate nanoparticles as adjuvants and vaccine delivery vehicles
Vaccination is one of the most efficacious and cost-effective ways to protect people from
infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole …
infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole …
[HTML][HTML] Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine
M Kopp, UW Aufderhorst, M Alt, U Dittmer… - … , Biology and Medicine, 2019 - Elsevier
Herpes simplex viruses 1 and 2 are among the most ubiquitous human infections and
persist lifelong in their host. Upon primary infection or reactivation from ganglia, the viruses …
persist lifelong in their host. Upon primary infection or reactivation from ganglia, the viruses …
Calcium phosphate nanoparticles as a new generation vaccine adjuvant
Y Lin, X Wang, X Huang, J Zhang, N Xia… - Expert review of …, 2017 - Taylor & Francis
Introduction: Adjuvants are essential components in vaccine formulations to induce robust
immunity against pathogens. The most widely used adjuvants in human vaccines are …
immunity against pathogens. The most widely used adjuvants in human vaccines are …
Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection
T Knuschke, W Bayer, O Rotan, V Sokolova… - … , Biology and Medicine, 2014 - Elsevier
Retroviral infections eg HIV still represent a unique burden in the field of vaccine research. A
common challenge in vaccine design is to find formulations that create appropriate immune …
common challenge in vaccine design is to find formulations that create appropriate immune …
Nanoparticle-based B-cell targeting vaccines: Tailoring of humoral immune responses by functionalization with different TLR-ligands
C Zilker, D Kozlova, V Sokolova, H Yan, M Epple… - … , Biology and Medicine, 2017 - Elsevier
Induction of an appropriate type of humoral immune response during vaccination is
essential for protection against viral and bacterial infections. We recently observed that …
essential for protection against viral and bacterial infections. We recently observed that …
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