Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction

Y Matsumura, Y Zhu, H Jiang, A D'Amore, SK Luketich… - Biomaterials, 2019 - Elsevier
Intramyocardial hydrogel injection is an innovative and promising treatment for myocardial
infarction (MI) and has recently entered clinical trials. By providing mechanical support to the …

Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

T Yoshizumi, Y Zhu, H Jiang, A D'Amore, H Sakaguchi… - Biomaterials, 2016 - Elsevier
Intramyocardial injection of various injectable hydrogel materials has shown benefit in
positively impacting the course of left ventricular (LV) remodeling after myocardial infarction …

Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model

JL Ifkovits, E Tous, M Minakawa… - Proceedings of the …, 2010 - National Acad Sciences
A recent trend has emerged that involves myocardial injection of biomaterials, containing
cells or acellular, following myocardial infarction (MI) to influence the remodeling response …

Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction

TD Johnson, KL Christman - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: Heart failure following myocardial infarction (MI) impacts millions of people
each year in the US. The field of tissue engineering has developed several potential …

Injectable hydrogels for cardiac tissue repair after myocardial infarction

A Hasan, A Khattab, MA Islam, KA Hweij… - Advanced …, 2015 - Wiley Online Library
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of
mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical …

Injectable shear-thinning hydrogels for minimally invasive delivery to infarcted myocardium to limit left ventricular remodeling

CB Rodell, ME Lee, H Wang… - Circulation …, 2016 - Am Heart Assoc
Background—Injectable, acellular biomaterials hold promise to limit left ventricular
remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct …

The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction

K Kadner, S Dobner, T Franz, D Bezuidenhout… - Biomaterials, 2012 - Elsevier
Biomaterials are increasingly being investigated as a means of reducing stress within the
ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of …

Injectable acellular hydrogels for cardiac repair

E Tous, B Purcell, JL Ifkovits, JA Burdick - Journal of cardiovascular …, 2011 - Springer
Injectable hydrogels are being developed as potential translatable materials to influence the
cascade of events that occur after myocardial infarction. These hydrogels, consisting of both …

Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction

SB Seif-Naraghi, JM Singelyn, MA Salvatore… - Science translational …, 2013 - science.org
New therapies are needed to prevent heart failure after myocardial infarction (MI). As
experimental treatment strategies for MI approach translation, safety and efficacy must be …

How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium

DS Li, R Avazmohammadi, CB Rodell, EW Hsu… - Acta biomaterialia, 2020 - Elsevier
Expansion of myocardium after myocardial infarction (MI) has long been identified as the
primary mechanism that drives adverse left ventricular (LV) remodeling towards heart failure …