Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction
Intramyocardial hydrogel injection is an innovative and promising treatment for myocardial
infarction (MI) and has recently entered clinical trials. By providing mechanical support to the …
infarction (MI) and has recently entered clinical trials. By providing mechanical support to the …
Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction
Intramyocardial injection of various injectable hydrogel materials has shown benefit in
positively impacting the course of left ventricular (LV) remodeling after myocardial infarction …
positively impacting the course of left ventricular (LV) remodeling after myocardial infarction …
Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model
JL Ifkovits, E Tous, M Minakawa… - Proceedings of the …, 2010 - National Acad Sciences
A recent trend has emerged that involves myocardial injection of biomaterials, containing
cells or acellular, following myocardial infarction (MI) to influence the remodeling response …
cells or acellular, following myocardial infarction (MI) to influence the remodeling response …
Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction
TD Johnson, KL Christman - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: Heart failure following myocardial infarction (MI) impacts millions of people
each year in the US. The field of tissue engineering has developed several potential …
each year in the US. The field of tissue engineering has developed several potential …
Injectable hydrogels for cardiac tissue repair after myocardial infarction
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of
mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical …
mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical …
Injectable shear-thinning hydrogels for minimally invasive delivery to infarcted myocardium to limit left ventricular remodeling
CB Rodell, ME Lee, H Wang… - Circulation …, 2016 - Am Heart Assoc
Background—Injectable, acellular biomaterials hold promise to limit left ventricular
remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct …
remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct …
The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction
K Kadner, S Dobner, T Franz, D Bezuidenhout… - Biomaterials, 2012 - Elsevier
Biomaterials are increasingly being investigated as a means of reducing stress within the
ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of …
ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of …
Injectable acellular hydrogels for cardiac repair
E Tous, B Purcell, JL Ifkovits, JA Burdick - Journal of cardiovascular …, 2011 - Springer
Injectable hydrogels are being developed as potential translatable materials to influence the
cascade of events that occur after myocardial infarction. These hydrogels, consisting of both …
cascade of events that occur after myocardial infarction. These hydrogels, consisting of both …
Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction
SB Seif-Naraghi, JM Singelyn, MA Salvatore… - Science translational …, 2013 - science.org
New therapies are needed to prevent heart failure after myocardial infarction (MI). As
experimental treatment strategies for MI approach translation, safety and efficacy must be …
experimental treatment strategies for MI approach translation, safety and efficacy must be …
How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium
Expansion of myocardium after myocardial infarction (MI) has long been identified as the
primary mechanism that drives adverse left ventricular (LV) remodeling towards heart failure …
primary mechanism that drives adverse left ventricular (LV) remodeling towards heart failure …