[HTML][HTML] Different DNA end configurations dictate which NHEJ components are most important for joining efficiency

HHY Chang, G Watanabe, CA Gerodimos… - Journal of Biological …, 2016 - ASBMB
The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing
dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are …

Non‐homologous end joining: common interaction sites and exchange of multiple factors in the DNA repair process

SL Rulten, GJ Grundy - Bioessays, 2017 - Wiley Online Library
Non‐homologous end‐joining (NHEJ) is the dominant means of repairing chromosomal
DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins …

[HTML][HTML] Nonhomologous DNA end-joining for repair of DNA double-strand breaks

NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

[PDF][PDF] A biochemically defined system for mammalian nonhomologous DNA end joining

Y Ma, H Lu, B Tippin, MF Goodman, N Shimazaki… - Molecular cell, 2004 - cell.com
Nonhomologous end joining (NHEJ) is a major pathway in multicellular eukaryotes for
repairing double-strand DNA breaks (DSBs). Here, the NHEJ reactions have been …

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

DA Reid, S Keegan, A Leo-Macias… - Proceedings of the …, 2015 - National Acad Sciences
Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA double-strand
breaks (DSBs), involving synapsis and ligation of the broken strands. We describe the use of …

Nonhomologous end joining: new accessory factors fine tune the machinery

D Ghosh, SC Raghavan - Trends in Genetics, 2021 - cell.com
Nonhomologous DNA end joining (NHEJ) is one of the major DNA double-strand break
(DSB) repair pathways in eukaryotes. The well-known critical proteins involved in NHEJ …

Defining interactions between DNA-PK and ligase IV/XRCC4

HL Hsu, SM Yannone, DJ Chen - DNA repair, 2002 - Elsevier
Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand
breaks (DSBs) in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and …

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

CA Koch, R Agyei, S Galicia, P Metalnikov… - The EMBO …, 2004 - embopress.org
Nonhomologous end joining (NHEJ) is the major DNA double‐strand break (DSB) repair
pathway in mammalian cells. A critical step in this process is DNA ligation, involving the …

Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system

KJ Lee, M Jovanovic, D Udayakumar, CL Bladen… - DNA repair, 2004 - Elsevier
Nonhomologous end joining (NHEJ) is the principal mechanism for repairing DNA double-
strand breaks in mammalian cells. NHEJ requires at least three protein components: the …

The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

E Weterings, NS Verkaik, G Keijzers… - … and cellular biology, 2009 - Taylor & Francis
Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous
end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 …