Diabetic cardiomyopathy is characterized by structural alterations such as cardiomyocyte
hypertrophy, necrosis and focal fibrosis. Hyperglycemia-induced oxidative damage may play …

Diabetic cardiomyopathy (DCM) is characterized by structural alterations such as
cardiomyocyte hypertrophy, necrosis and focal fibrosis. Poly (ADP-ribose) polymerase 1 …

Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and vascular
complications, which underlie the development of retinopathy, nephropathy, and neuropathy …

Abstract Poly (ADP-ribose) polymerase (PARP) activation has been implicated in the
pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the …

Cardiovascular complications are the major causes of mortality among diabetic population.
Poly (ADP-ribose) polymerase-1 enzyme (PARP-1) is activated by oxidative stress leading …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and a growing family of additional, novel poly (ADP-ribosylating) …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in regulating genome
stability, cell cycle progression, and cell survival. However, overactivation of PARP has been …

Abstract Type 2 diabetes mellitus (DM2) follows impaired glucose tolerance in obesity and is
frequently associated with hypertension, causing adverse myocardial remodelling and …

Activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP)-1 by oxidant-
mediated DNA damage is an important pathway of cell dysfunction and tissue injury during …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …