Mitochondria are the metabolic powerhouses of cells. In addition to generating adenosine
triphosphate (ATP), they play important roles in cell survival pathways such as apoptosis …

Significance: Cardiac function is energetically demanding, reliant on efficient well-coupled
mitochondria to generate adenosine triphosphate and fulfill the cardiac demand. Predictably …

The heart must function continuously as it is responsible for both supplying oxygen and
nutrients throughout the entire body, as well as for the transport of waste products to …

The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac
adaptation to pressure or volume overload is associated with a complex molecular change …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Alterations in mitochondrial function and morphology are critical adaptations to
cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular …

Metabolic diseases (MetDs) embrace a series of pathologies characterized by abnormal
body glucose usage. The known diseases included in this group are metabolic syndrome …

Cardiovascular disease is common in patients with diabetes and is a significant contributor
to the high mortality rates associated with diabetes. Heart failure is common in diabetic …

Muscle mitochondrial metabolism is a tightly controlled process that involves the
coordination of signaling pathways and factors from both the nuclear and mitochondrial …

Significance: Mitochondria are the cellular energy-producing organelles and are at the
crossroad of determining cell life and death. As such, the function of mitochondria has been …