Tissue homeostasis is the result of a complex intercellular network controlling the behavior
of every cell for the survival of the whole organism. In mammalian tissues, cells do …

Prostate cancer is a prevalent disease that is characterized by a presumably long latency
period and a moderate propensity to metastasize. Although a range of mechanisms have …

The development of many forms of intercellular communication was essential for the
evolution of multicellular organisms. The organization of cells into tissues and organs and …

Gap junctions, composed of connexins, provide a pathway of direct intercellular
communication for the diffusion of small molecules between cells. Evidence suggests that …

Gap‐junction‐mediated intercellular communication (GJIC) is required for completion of
embryonic development, tissue homeostasis, and regulation of cell proliferation and death …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell
communication, have been implicated in prostate cancer growth. To elucidate the crucial …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …