Orthodontic patients complain of pain for the first few days after insertion of appliances.
Mechanical force has been reported to produce oxidants in periodontal ligament (PDL) cells …

Orthodontic force produces mechanical irritation and localized inflammation in the
periodontium, which causes pain in most patients. Nocifensive behaviors resulting from …

Orthodontic force produces mechanical irritation and inflammation in the periodontium,
which is inevitably accompanied by pain. Despite its prevalence, treatment of orthodontic …

Objective The aim of this study was to quantify the temporal changes in inflammation and
TRPA1, TRPV1 and CGRP expression in the trigeminal ganglion during force-induced …

Background Oxidative stress has a critical effect on both persistent pain states and
periodontal disease. Voltage-gated sodium NaV1. 7 (SCN9A), and transient receptor …

Objective The objective of this study was to evaluate the role of nitric oxide synthase (NOS)
isoforms influence during tooth movement with different forces. Settings and sample …

Purpose Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is a
promiscuous chemical nociceptor involved in the perception of cold hypersensitivity …

Introduction The transient receptor potential (TRP) ion channels have emerged as important
cellular sensors in both neuronal and non-neuronal cells, with TRPA1 playing a central role …

Hyperalgesia has become a major problem restricting the clinical application of tooth
bleaching. We hypothesized that transient receptor potential ankyrin 1 (TRPA1), a pain …

During dental treatments, intraoral appliances frequently induce traumatic ulcers in the oral
mucosa. Such mucosal injury-induced mucositis leads to severe pain, resulting in poor …